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KMID : 0104920190280020001
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Journal of Hawhwa Medicine
2019 Volume.28 No. 2 p.1 ~ p.11
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Analysis for cancer-related studies using Puffer fish poison
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Cho Yong-Rae
Lee Sung-Bae
Park Samuel Young
Son Chang-Gue
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Abstract
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Objective: The aim of this study is to analyze the previously published research articles related to puffer fish toxin focusing on tumor.
Method: Literatures were searched in PubMed database, published since 2000, using the keyword; Puffer fish, Fugu and tetrodotoxin (TTX) with cancer or tumor. Research papers were classified by year, country, study model, used material, kind of tumor and study subject. Finally, a total of 41 studies were analyzed in this study.
Results: From 2000 to 2018, the most abundant papers were published in 2009 (6 studies) and almost half of the papers were studied in United Kingdom (20 studies). The 39 studies used TTX purified from puffer fish while 2 studies used crude extract of skin and gonad of puffer fish. The most used target cell line was prostate cancer (15 studies), and the next was breast cancer (14 studies). The study methods were classified into 4 clinical studies, 2 animal studies and 35 cell-based studies.
Conclusions: Our results show that the overview of cancer-related studies using puffer fish poison. This information would be helpful for the puffer fish-derived drug researches in the future.
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KEYWORD
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Puffer fish, Tetrodotoxin, TTX, Cancer, Tumor
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